Australian researchers have found through experiments in mice that the immune system cannot respond effectively to local infections when it produces a systemic immune response, which means that some chronic diseases or infections are caused Systemic inflammation may affect the effectiveness of vaccination.
This study by the Peter Dougherty Institute of Infection and Immunity explored how the immune system balances the two reactions when local and systemic immune responses occur simultaneously. Studies have found that when dealing with systemic inflammation, white blood cells (immune cells) will transfer from local lymph nodes to various parts of the body, inhibiting the body's response to local infections. The study also found that the key substance that hinders local reactions is a protein with defensive function-interferon.
The researchers further explored the impact of this discovery on vaccination, because most vaccines are injected locally in the arm and other places to trigger an antibody response and protect the body from subsequent infections.
In an interview with reporters, Scott Miller, director of the laboratory of the Department of Microbiology and Immunology of the Institute, said: "Our research shows that acute systemic inflammation caused by viral infection is not conducive to local immune response or vaccination. It can be speculated that other diseases that cause chronic inflammation of the whole body may also affect the effect of vaccination."
Related research papers have been published in the American "Cell Report" magazine.
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